January 2016

Recruitment now closed

The TABLET trial has closed to recruitment; the TABLET team have surpassed their target and recruited 952 women into the trial. Results from the trial will be available in spring 2018. They will spend the next 18 months following up women and their pregnancy status. The team would like to thank everybody for their support.

June 2015

Update on TABLET (Thyroid AntiBodies and LEvoThyroxine) trial

The trial started recruitment in late 2011 and is due to end recruitment in December 2015 with follow up to end in October 2017. So far 688 patients have been recruited and over 15,000 have been screened for the thyroid antibody. The Trial is open nationally in 48 sites, nine of which have been opened recently. It is hoped that this final cohort of sites will boost recruitment figures so that the target of 900 is met.

If you would like to take part in the trial contact the TABLET team on 0121 4159111 or email tablet-trial@trials.bham.ac.uk

More information is available at:
www.birmingham.ac.uk/TABLET

Project lead: Professor Arri Coomarasamy

The TABLET trial is a randomised, double-blind, placebo-controlled trial which is looking at the role of thyroid antibodies in miscarriage. There is evidence that thyroid antibodies can influence important pregnancy outcomes such as increasing the risk of miscarriage and delivering a baby prematurely. The TABLET Trial is a national study in which all women trying for a pregnancy under the age of 41 are invited to have a blood test to see if they have thyroid antibodies.

We are particularly interested in seeing whether a drug called Levothyroxine reduces the risk of miscarriage in women who have thyroid antibodies even though their thyroid hormones are in the normal range.

The lead researchers are keen to recruit as many women as possible so they can be sure that numbers are big enough to make the eventual results reliable. So if you might be interested in taking part, here’s what you need to know:

Who can take part?

The researchers are recruiting women who:

  • are aged 16 – 40
  • hope to conceive in the next year
  • Have had a previous miscarriage or due to have treatment for infertility
  • do not have known thyroid disease – and
  • are willing to be selected at random to have either the treatment or a placebo, without knowing which they are given.

Where is it taking place?

The following hospitals are currently recruiting patients:

Where is it taking place?

The following hospitals are currently recruiting patients:

Arrowe Park Hospital, Wirral near Liverpool
St Bartholomew's Hospital, London
Royal London Hospital, London
Whipps Cross Hospital, London
Newham University Hospital, London
Basildon Hospital, Basildon
Royal United Hospital, Bath
Birmingham Heartlands Hospital, Birmingham
Birmingham Women's Hospital, Birmingham
Royal Bolton Hospital, Bolton
Royal Bournemouth hospital, Bournemouth
Bradford Royal Infirmary, Bradford
St Michael's Hospital, Bristol
Birmingham City Hospital, Birmingham
Colchester General Hospital,Colchester
Countess of Chester Health Park, Chester
University Hospital Coventry, Coventry
Crosshouse Hospital, Kilmarnock
Cumberland Infirmary, Cumberland
Royal Derby Hospital, Derby
Derriford Hospital, Plymouth
University Hospital North Durham , Durham
Ealing Hospital, Borough of London
Burnley General Hospital, Burnley
Frimley Park Hospital, Frimley, Surrey
Furness General Hospital, Cumbria
Guy's Hospital, London
James Cook University Hospital, Middlesborough
King's College Hospital, London
St James University Hospital, Leeds
Liverpool Women's Hospital, Liverpool
New Cross Hospital, Wolverhampton
Queens Medical Centre, Nottingham
Omskirk and District General Hospital, Omskirk
North Manchester General Hospital, Manchester
Fairfield General Hospital, Bury
Rochdale Infirmary, Manchester
Royal Oldham Hospital, Manchester
Princess Royal Hospital, Telford
Royal Shrewsbury Hospital, Shrewsbury
Royal Cornwall Hospital, Cornwall
Royal Devon and Exeter Hospital, Devon
The Royal Victoria Infirmary,Newcastle upon Tyne.
St Mary's Hospital, London
St Mary's Hospital, Manchester
St Peters Hospital, Chertsey
St Thomas Hospital, London
University College Hospital, London
Warrington Hospital, Warrington
Watford General Hospital, Watford
West Middlesex University Hospital, Middlesex
Wrightington Hospital, Wrightington
University Hospitals of North Tees, Cleveland

There is also further information on the trial website

The trial is funded by Evaluation of Efficacy and Mechanism (EME) programme of the Medical Research Council (MRC, UK). The study has full ethical approval from NRES Committee South West - Central Bristol Ref 11/SW/0036 – EudraCT 000719-19

If you would like to take part but don’t live near one of these centres, you may still be eligible to join the trial. Please contact the TABLET office at tablet-trial@trials.bham.ac.uk. If you have other questions or concerns about the trial, you can contact Krys Baker TABLET Trial Co-ordinator k.baker@bham.ac.uk or TABLET Research Fellow Dr. Rima Dhillon rima.dhillon@doctors.org.uk

 

TABLET April 2010

TABLET update October 2011