September 2017 - The following are research projects involving young people with thyroid disease in the UK. This is not a comprehensive list and there are other projects underway or being planned.

Study of Graves’ disease in young people

The clinical trial that is looking to see if the medicine Rituximab can improve outcomes in young people diagnosed with Graves’ disease is now well underway. Eligible patients are aged 12 to 20 years who have recently been diagnosed and hence have been on Carbimazole for less than six weeks. Collaborating centres include Birmingham, Cardiff, Doncaster, Edinburgh, Leeds, Newcastle, Sheffield and Southampton. If you would like any more details about the trial or if you would like to know if you are eligible then please speak to your local doctor or contact Tim Cheetham by email at tim.cheetham@nuth.nhs.uk

 

The National BSPED Thyrotoxicosis Study

This study, supported by the BTF is looking at how best to administer anti-thyroid drugs (usually carbimazole in the UK) to children and adolescents with thyrotoxicosis. The study finished in 2015 and over 80 patients were recruited from around 15 centres in England, Scotland and Wales. The data is currently being put in the correct format so that analysis can begin. The medicine side-effect information is very important in this trial and we have been making sure that this is accurately categorised. The analysis of the data will be conducted by a professor in medical statistics at Newcastle University and will begin in the very near future. Many people will have heard about this trial over the years and we are sorry that analysing the data (and hence working out what the trial has taught us) is taking so long.

Contact: tim.cheetham@nuth.nhs.uk

The British Paediatric Surveillance study of congenital hypothyroidism (CHT)

This study has been looking at the incidence of CHT in the UK (how common it is) and other important issues such as what proportion of cases are temporary as opposed to permanent. The study will also provide information about how paediatricians manage the condition in the UK. The study is supported by the Royal College of Paediatrics and Child Health (RCPCH) and received backing from the BTF. We expect that results from this study will start to appear in the medical literarture in 2016-2017 which will be very exciting.

Contact: Rachel Knowles  r.knowles@ich.ucl.ac.uk

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