As a patient-led organisation, BTF is often asked by medical and other professionals for help with research projects. After completion, findings are often published in the BTF News or in the research news section.
Patients needed for Graves’ disease research study
Illingworth Research Group Ltd is coordinating a phase I study investigating a potential new drug, K1-70, developed to treat patients who have Graves’ disease, thyroid cancer, and patients who would benefit from controlling thyroid stimulating hormone receptor activity. A Safety Review Committee found the drug to have been safe and well-tolerated in the patients treated so far.
A further eight patients with Graves’ disease are needed to complete this study. Travel to and from the study sites is provided from a patient’s chosen location, as well as accommodation for patients travelling from far. For more information, please contact:
- volunteer Services team at the Medicines Evaluation Unit on 0800 655 6553 and quote study MEU 15/304
- recruitment Team at the Royal Liverpool and Broadgreen Clinical research Facility between 8.00am and 4.00pm on 0151 706 4863 and quote study CRU/5464 or text CRU/5464 to 07342065915
Main Inclusion Criteria
- age 18-75 years, male or female
- have Graves' disease and are being treated with anti-thyroid medications OR not treated with anti-thyroid medications (due to side-effects) and who are clinically and biochemically euthyroid or hyperthyroid
- have a body mass index (weight [kg]/height [m]2) between 18.5 and 35.0 kg/m2
Main Exclusion Criteria
- current or chronic history of liver disease
- history of cancer within the last 5 years except localised skin cancer
- Graves' orbitopathy with clinical activity score >3/7
- evidence of optic neuropathy and/or corneal breakdown
- significant systemic infection
- history of recurrent or current infection
- recently had major surgery or plan major surgery
- had thromboembolic event due to a blood clot in the last 12 months
- have clinically significant laboratory tests
- a clinically significant allergic condition (excluding hay fever)
- currently receiving corticosteroids
- smoke more than 10 cigarettes (or its equivalent) per day
- history of drug abuse
- pregnant women and male subjects with pregnant female partners
Levothyroxine Replacement in the 21st Century
This survey is now closed - we needed 1000 responses, and we got them... and in record time! Thank you to everyone who participated in the survey - we're grateful for your input which will help to inform the development of treatment for hypothyroidism.
Hypothyroidism (underactive thyroid) affects many people worldwide and yet patients’ reported satisfaction levels with their treatment and care vary widely. If you or your child have been diagnosed with hypothyroidism please take part in our survey, which will take less than 5 minutes to complete. Your feedback is important - your views will help to inform future research and bring about improvements for patients. Thank you for participating.
Study of Graves' Disease in Young People
The clinical trial that is looking to see if the medicine Rituximab can improve outcomes in young people diagnosed with Graves’ disease (the RIG-D trial) finished recruiting participants in August 2018. We expect the results of this trail to be available towards the end of 2020. If you would like information regarding the background to the trial then contact Tim Cheetham by email at email@example.com
Thyroid Receptor Dysfunction Research Project
We are looking for volunteers who have been diagnosed with thyroid receptor dysfunction to come along and take part in a research project at Moorfields Eye Hospital. This research is trying to identify the mechanism by which thyroid receptor dysfunction impacts on vision and in particular, people’s colour vision. This will be a key step towards finding treatments for this and similar genetic eye disorder.
If you are interested in taking part, you would need to be free to attend Moorfields for a short visit (about one hour) in the coming months. The test involves sitting at a computer and clicking either a left or right button when images appear on the screen. The test is completely non-invasive, we will not be giving you any medications, you will not have to wear any special glasses or eye patches to take the test. All travel costs will be reimbursed.
For more information or to find out how to take part please contact: Dr. Matteo Rizzi,firstname.lastname@example.org, tel. 07835164303
When you were diagnosed with thyroid eye disease, what support was helpful to you? Was your GP able to help you? What was missing?
We're very interested to hear of your experience which will be helpful for the BTF's thyroid eye disease project as well as for a group of GPs to whom we are speaking, and will help to bring about improvements for future patients. Any information we share with the GPs will remain anonymous. Please email Janis Hickey at: email@example.com
Thank you for your help.